BAIT
GDF6
BMP-13, BMP13, CDMP2, KFM, KFS, KFS1, KFSL, LCA17, MCOP4, MCOPCB6, SCDO4, SGM1
growth differentiation factor 6
GO Process (11)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- SMAD protein signal transduction [IBA]
- activin receptor signaling pathway [IDA]
- apoptotic process [ISS]
- cell development [IBA]
- pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of MAPK cascade [IBA]
- regulation of apoptotic process [IBA]
- retinal cell apoptotic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BMPR1B
ALK-6, ALK6, CDw293
bone morphogenetic protein receptor, type IB
GO Process (11)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, NAS, TAS]
- cartilage condensation [NAS]
- eye development [ISS]
- limb morphogenesis [IMP]
- ovarian cumulus expansion [ISS]
- ovulation cycle [ISS]
- positive regulation of bone mineralization [IMP]
- positive regulation of cell differentiation [IMP]
- positive regulation of osteoblast differentiation [IMP]
- protein phosphorylation [IDA]
- skeletal system development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis.
Cartilage-derived morphogenetic proteins-1 and -2 (CDMP-1 and CDMP-2) are members of the bone morphogenetic protein (BMP) family, which play important roles in embryonic skeletal development. We studied the biological activities of recombinant CDMP-1 and CDMP-2 in chondrogenic and osteogenic differentiation and investigated their binding properties to type I and type II serine/threonine kinase receptors. In vivo, CDMP-1 and CDMP-2 were ... [more]
J. Bone Miner. Res. Mar. 01, 1998; 13(3);383-92 [Pubmed: 9525338]
Throughput
- Low Throughput
Curated By
- BioGRID