BAIT

UTY

KDM6AL, UTY1
ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

TLE2

ESG, ESG2, GRG2
transducin-like enhancer of split 2
UPS Project
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms.

Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S

The yeast proteins TUP1 and SSN6 form a transcription repressor complex that is recruited to different promoters via pathway-specific DNA-binding proteins and regulates the expression of a variety of genes. TUP1 is functionally related to invertebrate and vertebrate transcriptional repressors of the Groucho/transducin-like Enhancer of split (TLE) family. The aim was to examine whether similar mechanisms underlie the transcription repression ... [more]

Biochem. J. Jan. 01, 1999; 337(0);13-7 [Pubmed: 9854018]

Throughput

  • Low Throughput

Curated By

  • BioGRID