PDGFRA
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cardiac myofibril assembly [ISS]
- cell activation [TAS]
- cell chemotaxis [IMP]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic digestive tract morphogenesis [ISS]
- embryonic skeletal system morphogenesis [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- luteinization [ISS]
- metanephric glomerular capillary formation [ISS]
- negative regulation of platelet activation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [IMP, TAS]
- platelet aggregation [IMP]
- platelet-derived growth factor receptor signaling pathway [IDA]
- platelet-derived growth factor receptor-alpha signaling pathway [IMP]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [IMP]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton reorganization [TAS]
- regulation of chemotaxis [IMP]
- regulation of mesenchymal stem cell differentiation [IMP]
- retina vasculature development in camera-type eye [ISS]
- wound healing [ISS]
Gene Ontology Molecular Function- platelet-derived growth factor alpha-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
- platelet-derived growth factor alpha-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
Gene Ontology Cellular Component
PDGFC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.
We have characterized platelet-derived growth factor (PDGF) C, a novel growth factor belonging to the PDGF family. PDGF-C is a multidomain protein with the N-terminal region homologous to the extracellular CUB domain of neuropilin-1, and the C-terminal region consists of a growth factor domain (GFD) with homology to vascular endothelial growth factor (25%) and PDGF A-chain (23%). A serum-sensitive cleavage ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PDGFRA PDGFC | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.01 | BioGRID | 3508576 | |
| PDGFRA PDGFC | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID