An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

Liu Y, Zhang X, Lin J, Chen Y, Qiao Y, Guo S, Yang Y, Zhu G, Pan Q, Wang J, Sun F

Although Yes-associated protein (YAP) is very important to liver cancer, its nuclear localisation prevents consideration as a promising therapeutic target and a diagnostic biomarker. Recently, we reported that the protumourigenic roles of YAP in liver cancer are indispensable for transcription factor CP2 (TFCP2) in a Hippo-independent manner; however, proteins that act upstream to simultaneously control YAP and TFCP2 remain unclear. ... [more]

Cell Death Dis Dec. 09, 2018; 10(9);644 [Pubmed: 31501420]

Throughput

High Throughput

Additional Notes

assayed using MS (mass spectrometry); hit proteins interacted with both YAP1 and TFCP2

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
TFCP2 CORO1C	Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.	Havugimana PC (2022)	High	-	BioGRID	3449284

Curated By

BioGRID

Interaction Summary

TFCP2

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [TAS]sequence-specific DNA binding [IBA]sequence-specific DNA binding transcription factor activity [TAS]

Gene Ontology Cellular Component

CORO1C