BAIT
RIMS2
Nim2, Rim2
regulating synaptic membrane exocytosis 2
GO Process (10)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cAMP-mediated signaling [ISO, ISS]
- calcium ion-dependent exocytosis [ISO, ISS]
- calcium ion-dependent exocytosis of neurotransmitter [ISO, ISS]
- exocytosis [TAS]
- insulin secretion [ISO, ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of inhibitory postsynaptic membrane potential [ISS]
- regulation of exocytosis [ISO, ISS]
- regulation of membrane potential [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAB3A
RAB3
RAB3A, member RAS oncogene family
GO Process (23)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA, IC]
- axonogenesis [ISO]
- intracellular protein transport [IBA]
- lung development [ISO]
- maintenance of presynaptic active zone structure [ISO]
- mitochondrion organization [ISO]
- neuromuscular synaptic transmission [ISO]
- positive regulation of ATPase activity [IDA]
- positive regulation of regulated secretory pathway [ISO]
- post-embryonic development [ISO]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of exocytosis [IBA, ISO]
- regulation of short-term neuronal synaptic plasticity [ISS]
- regulation of synaptic vesicle fusion to presynaptic membrane [ISO, ISS]
- respiratory system process [ISO]
- response to electrical stimulus [ISO]
- sensory perception of touch [ISO]
- synaptic vesicle exocytosis [IMP, ISO]
- synaptic vesicle maturation [ISO]
- synaptic vesicle recycling [IMP]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins.
RIM1 is a putative effector protein for Rab3s, synaptic GTP-binding proteins. RIM1 is localized close to the active zone at the synapse, where it interacts in a GTP-dependent manner with Rab3 located on synaptic vesicles. We now describe a second RIM protein, called RIM2, that is highly homologous to RIM1 and also expressed primarily in brain. Like RIM1, RIM2 contains ... [more]
J. Biol. Chem. Jun. 30, 2000; 275(26);20033-44 [Pubmed: 10748113]
Throughput
- Low Throughput
Curated By
- BioGRID