RIMS2
Gene Ontology Biological Process
- cAMP-mediated signaling [ISO, ISS]
- calcium ion-dependent exocytosis [ISO, ISS]
- calcium ion-dependent exocytosis of neurotransmitter [ISO, ISS]
- exocytosis [TAS]
- insulin secretion [ISO, ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of inhibitory postsynaptic membrane potential [ISS]
- regulation of exocytosis [ISO, ISS]
- regulation of membrane potential [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB3C
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- antigen processing and presentation [ISO]
- intracellular protein transport [IBA]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of exocytosis [IBA, ISO]
- synaptic vesicle exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins.
RIM1 is a putative effector protein for Rab3s, synaptic GTP-binding proteins. RIM1 is localized close to the active zone at the synapse, where it interacts in a GTP-dependent manner with Rab3 located on synaptic vesicles. We now describe a second RIM protein, called RIM2, that is highly homologous to RIM1 and also expressed primarily in brain. Like RIM1, RIM2 contains ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID