Publication

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

Pladevall-Morera D, Munk S, Ingham A, Garribba L, Albers E, Liu Y, Olsen JV, Lopez-Contreras AJ

Common fragile sites (CFSs) are conserved genomic regions prone to break under conditions of replication stress (RS). Thus, CFSs are hotspots for rearrangements in cancer and contribute to its chromosomal instability. Here, we have performed a global analysis of proteins that recruit to CFSs upon mild RS to identify novel players in CFS stability. To this end, we performed Chromatin ... [more]

Throughput

• High Throughput

Additional Notes

• hit proteins associated with FANCD2 but were not '...at least 1.5-fold higher abundance in the FANCD2 pull-down compared to IgG from synchronized and APH (aphidicolin) treated cells in more than half of the experiments from which they were identified'

Curated By

• BioGRID