FLNA
Gene Ontology Biological Process
- actin crosslink formation [ISO]
- actin cytoskeleton organization [IGI]
- actin cytoskeleton reorganization [ISO]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [ISO]
- cilium assembly [ISO]
- cytoplasmic sequestering of protein [ISO]
- early endosome to late endosome transport [IDA]
- epithelial to mesenchymal transition [IGI]
- establishment of protein localization [ISO]
- mRNA transcription from RNA polymerase II promoter [ISO]
- negative regulation of protein catabolic process [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- platelet aggregation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- protein localization to cell surface [ISO]
- protein stabilization [ISO]
- receptor clustering [ISO]
- spindle assembly involved in mitosis [ISO]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Myb complex [ISO]
- actin cytoskeleton [ISO]
- actin filament [ISO]
- actin filament bundle [IDA]
- apical dendrite [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendritic shaft [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- trans-Golgi network [IDA]
FURIN
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cell proliferation [IMP]
- cellular protein metabolic process [TAS]
- collagen catabolic process [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of low-density lipoprotein particle receptor catabolic process [IDA]
- negative regulation of nerve growth factor production [IDA]
- negative regulation of transforming growth factor beta1 production [IMP]
- nerve growth factor processing [TAS]
- nerve growth factor production [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptide biosynthetic process [IDA]
- peptide hormone processing [IDA]
- peptidyl-glutamic acid carboxylation [TAS]
- positive regulation of membrane protein ectodomain proteolysis [IC]
- post-translational protein modification [TAS]
- protein processing [IDA, IMP]
- proteolysis [TAS]
- regulation of endopeptidase activity [IDA]
- regulation of protein catabolic process [IMP]
- secretion by cell [IDA]
- signal peptide processing [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
- viral life cycle [IEP]
- viral process [TAS]
- viral protein processing [TAS]
- virion assembly [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway.
Furin catalyzes the proteolytic maturation of many proproteins within the trans-Golgi network (TGN)/endosomal system. Furin's cytosolic domain (cd) directs both the compartmentalization to and transit between its manifold processing compartments (i.e., TGN/biosynthetic pathway, cell surface, and endosomes). Here we report the identification of the first furin cd sorting protein, ABP-280 (nonmuscle filamin), an actin gelation protein. The furin cd was ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FURIN FLNA | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| FURIN FLNA | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID