APBA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STX1A
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [ISO]
- intracellular protein transport [IBA]
- neurotransmitter transport [TAS]
- positive regulation of exocytosis [IDA]
- positive regulation of neurotransmitter secretion [IMP]
- regulation of exocytosis [IMP]
- response to gravity [IDA]
- secretion by cell [ISO]
- synaptic vesicle docking [IEP]
- synaptic vesicle fusion to presynaptic membrane [IBA]
Gene Ontology Molecular Function- ATP-dependent protein binding [IPI]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, IPI, ISO]
- calcium channel inhibitor activity [ISO]
- calcium-dependent protein binding [IPI]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [IDA]
- kinase binding [ISO]
- myosin binding [IPI]
- myosin head/neck binding [IPI]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein binding, bridging [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
- ATP-dependent protein binding [IPI]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, IPI, ISO]
- calcium channel inhibitor activity [ISO]
- calcium-dependent protein binding [IPI]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [IDA]
- kinase binding [ISO]
- myosin binding [IPI]
- myosin head/neck binding [IPI]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein binding, bridging [IPI]
- protein domain specific binding [IPI]
- protein heterodimerization activity [IDA]
Gene Ontology Cellular Component
- SNARE complex [ISO, ISS]
- actomyosin [IDA]
- cell [ISO]
- integral component of membrane [NAS]
- intracellular organelle [IDA]
- membrane [ISO]
- neuron projection [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA]
- secretory granule [IDA]
- synaptic vesicle [IBA, ISO]
- synaptic vesicle membrane [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.
Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. Mint proteins are detectable only in brain and are composed of an N-terminal sequence that binds Munc18-1, a middle phosphotyrosine-binding domain, and two C-terminal PDZ ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| APBA1 STX1A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID