APBA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SNAP25
Gene Ontology Biological Process
- axonogenesis [IEP]
- calcium ion-dependent exocytosis of neurotransmitter [IDA]
- endosomal transport [IDA]
- exocytosis [TAS]
- growth hormone secretion [IEP]
- long-term memory [IMP]
- long-term synaptic potentiation [ISO]
- neurotransmitter secretion [ISO]
- positive regulation of hormone secretion [IMP]
- positive regulation of insulin secretion [IEP]
- potassium ion transmembrane transport [IDA]
- regulation of establishment of protein localization [ISO]
- regulation of neuron projection development [IMP]
- regulation of synapse assembly [IEP]
- sleep [IDA]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- synaptic vesicle priming [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- BLOC-1 complex [ISO, ISS]
- SNARE complex [IDA, ISO]
- actin cytoskeleton [IDA]
- axon [IDA]
- axonal growth cone [IDA]
- cell [ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- endosome [IDA]
- filopodium [IDA]
- growth cone [IDA]
- intracellular organelle [IDA]
- lamellipodium [IDA]
- membrane [ISO, ISS]
- membrane raft [IDA]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- synapse [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [IDA]
- terminal bouton [IDA]
- trans-Golgi network [ISO]
- vesicle [ISO]
- voltage-gated potassium channel complex [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mints, Munc18-interacting proteins in synaptic vesicle exocytosis.
Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. Mint proteins are detectable only in brain and are composed of an N-terminal sequence that binds Munc18-1, a middle phosphotyrosine-binding domain, and two C-terminal PDZ ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID