PREY
PLEK
P47
pleckstrin
GO Process (25)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IDA]
- blood coagulation [TAS]
- cell projection organization [IDA]
- cortical actin cytoskeleton organization [IDA]
- hematopoietic progenitor cell differentiation [IEP]
- integrin-mediated signaling pathway [IDA]
- negative regulation of G-protein coupled receptor protein signaling pathway [IDA]
- negative regulation of calcium-mediated signaling [NAS]
- negative regulation of inositol phosphate biosynthetic process [IDA]
- phosphatidylinositol metabolic process [IDA]
- phospholipase C-inhibiting G-protein coupled receptor signaling pathway [IDA]
- platelet activation [TAS]
- platelet aggregation [IMP, ISS]
- platelet degranulation [IEP, TAS]
- positive regulation of actin filament bundle assembly [IDA]
- positive regulation of actin filament depolymerization [IDA]
- positive regulation of inositol-polyphosphate 5-phosphatase activity [IDA]
- positive regulation of integrin activation [ISS]
- positive regulation of platelet activation [ISS]
- protein kinase C signaling [ISS]
- protein secretion by platelet [ISS]
- regulation of cell diameter [IDA]
- ruffle organization [IDA]
- thrombin receptor signaling pathway [IDA]
- vesicle docking involved in exocytosis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.
Phagocytosis is required for a broad range of physiological functions, from pathogen defense to tissue homeostasis, but the mechanisms required for phagocytosis of diverse substrates remain incompletely understood. Here, we developed a rapid magnet-based phenotypic screening strategy, and performed eight genome-wide CRISPR screens in human cells to identify genes regulating phagocytosis of distinct substrates. After validating select hits in focused ... [more]
Nat. Genet. Dec. 01, 2017; 50(12);1716-1727 [Pubmed: 30397336]
Throughput
- High Throughput
Additional Notes
- BioID
- SAINT score thresold >/= 8
Curated By
- BioGRID