DLG3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BAIAP2
Gene Ontology Biological Process
- Rho protein signal transduction [TAS]
- actin crosslink formation [IMP]
- actin filament bundle assembly [IGI, IMP]
- dendrite development [IMP]
- positive regulation of dendritic spine morphogenesis [ISO]
- regulation of actin cytoskeleton organization [ISO]
- regulation of cell shape [IMP]
- regulation of synaptic plasticity [IMP]
- response to bacterium [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Insulin receptor substrate of 53 kDa links postsynaptic shank to PSD-95.
The insulin receptor substrate of 53 kDa (IRSp53) is a target of the small GTPase cdc42 which is strongly enriched in the postsynaptic density of excitatory synapses. IRSp53 interacts with the postsynaptic shank1 scaffolding molecule in a cdc42 regulated manner. The functional significance of the cdc42/IRSp53 pathway in postsynaptic sites is however, unclear. Here we identify PSD-95 as a second ... [more]
Throughput
- Low Throughput
Additional Notes
- Species of bait is unclear
Curated By
- BioGRID