BAIT
DLG3
MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR, RP11-291O7.3
discs, large homolog 3 (Drosophila)
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BAIAP2
IRSp53, R75030, RP23-390H16.1
brain-specific angiogenesis inhibitor 1-associated protein 2
GO Process (9)
GO Function (4)
GO Component (13)
Gene Ontology Biological Process
- Rho protein signal transduction [TAS]
- actin crosslink formation [IMP]
- actin filament bundle assembly [IGI, IMP]
- dendrite development [IMP]
- positive regulation of dendritic spine morphogenesis [ISO]
- regulation of actin cytoskeleton organization [ISO]
- regulation of cell shape [IMP]
- regulation of synaptic plasticity [IMP]
- response to bacterium [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Insulin receptor substrate of 53 kDa links postsynaptic shank to PSD-95.
The insulin receptor substrate of 53 kDa (IRSp53) is a target of the small GTPase cdc42 which is strongly enriched in the postsynaptic density of excitatory synapses. IRSp53 interacts with the postsynaptic shank1 scaffolding molecule in a cdc42 regulated manner. The functional significance of the cdc42/IRSp53 pathway in postsynaptic sites is however, unclear. Here we identify PSD-95 as a second ... [more]
J. Neurochem. Aug. 01, 2004; 90(3);659-65 [Pubmed: 15255944]
Throughput
- Low Throughput
Additional Notes
- Species of bait is unclear
Curated By
- BioGRID