BAIT
TNK2
Ack, Ack-1, Ack1, Cdgip, Pyk1
tyrosine kinase, non-receptor, 2
GO Process (9)
GO Function (7)
GO Component (13)
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- regulation of cell proliferation [IBA]
- regulation of clathrin-mediated endocytosis [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ANK2
AI835472, AW491075, Ank-2
ankyrin 2, brain
GO Process (33)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
- SA node cell action potential [IMP]
- SA node cell to atrial cardiac muscle cell communication [IMP]
- T-tubule organization [IMP]
- atrial cardiac muscle cell action potential [IMP]
- atrial cardiac muscle cell to AV node cell communication [IMP]
- cardiac muscle contraction [IMP]
- cellular calcium ion homeostasis [IMP]
- cellular protein localization [IMP]
- positive regulation of calcium ion transmembrane transporter activity [IMP]
- positive regulation of calcium ion transport [IMP]
- positive regulation of cation channel activity [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of potassium ion transmembrane transporter activity [IMP]
- positive regulation of potassium ion transport [IMP]
- protein localization [IMP]
- protein localization to M-band [IMP]
- protein localization to T-tubule [IMP]
- protein localization to cell surface [IMP]
- protein localization to endoplasmic reticulum [IMP]
- protein localization to plasma membrane [IMP]
- protein stabilization [IMP]
- protein targeting to plasma membrane [IGI, IMP]
- regulation of calcium ion transmembrane transporter activity [IMP]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cardiac muscle cell membrane potential [IGI, IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC, IMP]
- regulation of cation channel activity [IMP]
- regulation of heart rate [IMP]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of protein stability [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- A band [IDA]
- M band [IDA, IMP]
- T-tubule [IDA]
- Z disc [IDA]
- cell [IGI]
- costamere [IDA]
- cytoplasm [IDA]
- integral component of plasma membrane [IDA]
- intercalated disc [IDA]
- intracellular [IGI, IMP]
- neuronal postsynaptic density [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, IMP]
- sarcolemma [IDA, IMP]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.
Ack1 (activated Cdc42-associated tyrosine kinase) is a non-receptor tyrosine kinase that is highly expressed in brain. This kinase contains several protein-protein interaction domains and its action is partially regulated by phosphorylation. As a first step to address the neuronal functions of Ack1, here we screened mouse brain samples to identify proteins that interact with this kinase. Using mass spectrometry analysis, ... [more]
Oncotarget Nov. 24, 2017; 8(60);101146-101157 [Pubmed: 29254152]
Throughput
- High Throughput
Curated By
- BioGRID