BAIT
TNK2
Ack, Ack-1, Ack1, Cdgip, Pyk1
tyrosine kinase, non-receptor, 2
GO Process (9)
GO Function (7)
GO Component (13)
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- regulation of cell proliferation [IBA]
- regulation of clathrin-mediated endocytosis [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SRGAP2
9930124L22Rik, AI448945, FBP2, Fnbp2, srGAP3
SLIT-ROBO Rho GTPase activating protein 2
GO Process (10)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- actin filament severing [ISO]
- dendritic spine development [IMP, ISO]
- extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [IMP]
- filopodium assembly [IDA, ISO]
- lamellipodium assembly involved in ameboidal cell migration [ISO]
- negative regulation of cell migration [IBA]
- negative regulation of neuron migration [ISO]
- neuron projection morphogenesis [IMP]
- positive regulation of Rac GTPase activity [IDA, ISO]
- substrate adhesion-dependent cell spreading [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.
Ack1 (activated Cdc42-associated tyrosine kinase) is a non-receptor tyrosine kinase that is highly expressed in brain. This kinase contains several protein-protein interaction domains and its action is partially regulated by phosphorylation. As a first step to address the neuronal functions of Ack1, here we screened mouse brain samples to identify proteins that interact with this kinase. Using mass spectrometry analysis, ... [more]
Oncotarget Nov. 24, 2017; 8(60);101146-101157 [Pubmed: 29254152]
Throughput
- High Throughput
Curated By
- BioGRID