BAIT
TNK2
Ack, Ack-1, Ack1, Cdgip, Pyk1
tyrosine kinase, non-receptor, 2
GO Process (9)
GO Function (7)
GO Component (13)
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- regulation of cell proliferation [IBA]
- regulation of clathrin-mediated endocytosis [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NLGN3
A230085M13Rik, HNL3, NL3, RP23-440J15.4
neuroligin 3
GO Process (28)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- adult behavior [ISO]
- axon extension [ISO]
- learning [ISO]
- neuron cell-cell adhesion [IBA, ISO]
- oligodendrocyte differentiation [IMP]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of synapse assembly [ISO]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- postsynaptic membrane assembly [IMP]
- presynaptic membrane assembly [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of inhibitory postsynaptic membrane potential [IMP, ISO]
- regulation of long-term synaptic potentiation [IMP]
- regulation of respiratory gaseous exchange by neurological system process [IGI]
- regulation of synaptic transmission [IGI]
- regulation of synaptic transmission, glutamatergic [IMP]
- regulation of terminal button organization [IMP]
- rhythmic synaptic transmission [ISO]
- social behavior [IMP, ISO]
- synapse assembly [ISO]
- synapse organization [IGI, ISO]
- visual learning [IMP]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.
Ack1 (activated Cdc42-associated tyrosine kinase) is a non-receptor tyrosine kinase that is highly expressed in brain. This kinase contains several protein-protein interaction domains and its action is partially regulated by phosphorylation. As a first step to address the neuronal functions of Ack1, here we screened mouse brain samples to identify proteins that interact with this kinase. Using mass spectrometry analysis, ... [more]
Oncotarget Nov. 24, 2017; 8(60);101146-101157 [Pubmed: 29254152]
Throughput
- High Throughput
Curated By
- BioGRID