BAIT
TNK2
Ack, Ack-1, Ack1, Cdgip, Pyk1
tyrosine kinase, non-receptor, 2
GO Process (9)
GO Function (7)
GO Component (13)
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- regulation of cell proliferation [IBA]
- regulation of clathrin-mediated endocytosis [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PTK2B
CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, FAK2, PYK2, Raftk
PTK2 protein tyrosine kinase 2 beta
GO Process (72)
GO Function (8)
GO Component (18)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin filament organization [ISO]
- activation of Janus kinase activity [ISO]
- activation of Rac GTPase activity [ISO]
- angiogenesis [ISO]
- blood vessel endothelial cell migration [ISO]
- bone resorption [IMP]
- cell adhesion [ISO]
- cell surface receptor signaling pathway [ISO]
- cellular defense response [ISO]
- cellular response to retinoic acid [ISO]
- chemokine-mediated signaling pathway [IMP]
- epidermal growth factor receptor signaling pathway [IBA, ISO]
- focal adhesion assembly [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO]
- ionotropic glutamate receptor signaling pathway [ISO]
- long-term synaptic potentiation [ISO]
- marginal zone B cell differentiation [IMP]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone mineralization [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of myeloid cell differentiation [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of ossification [ISO]
- negative regulation of potassium ion transport [ISO]
- neuron projection development [ISO]
- oocyte maturation [ISO]
- peptidyl-tyrosine autophosphorylation [IBA, ISO]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of B cell chemotaxis [IMP]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of endothelial cell migration [IMP, ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of nitric-oxide synthase activity [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein kinase activity [IMP, ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- positive regulation of translation [ISO]
- protein phosphorylation [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- regulation of actin cytoskeleton reorganization [IMP]
- regulation of cGMP biosynthetic process [IMP]
- regulation of cGMP-mediated signaling [IMP]
- regulation of calcium-mediated signaling [IMP]
- regulation of cell adhesion [IBA, ISO]
- regulation of cell shape [IMP, ISO]
- regulation of establishment of cell polarity [IMP]
- regulation of inositol trisphosphate biosynthetic process [IMP]
- regulation of macrophage chemotaxis [IMP]
- regulation of nitric oxide biosynthetic process [IMP]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- regulation of release of sequestered calcium ion into cytosol [IMP]
- response to hydrogen peroxide [ISO]
- sprouting angiogenesis [IMP]
- stress fiber assembly [ISO]
- tumor necrosis factor-mediated signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
Gene Ontology Molecular Function- 3-phosphoinositide-dependent protein kinase binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- calmodulin-dependent protein kinase activity [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA]
- receptor binding [IBA]
- 3-phosphoinositide-dependent protein kinase binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [ISO]
- calmodulin-dependent protein kinase activity [ISO]
- non-membrane spanning protein tyrosine kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA]
- receptor binding [IBA]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISO]
- apical dendrite [ISO]
- axon [ISO]
- cell body [ISO]
- cell cortex [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendrite [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [ISO]
- growth cone [ISO]
- lamellipodium [ISO]
- membrane raft [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- postsynaptic density [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.
Ack1 (activated Cdc42-associated tyrosine kinase) is a non-receptor tyrosine kinase that is highly expressed in brain. This kinase contains several protein-protein interaction domains and its action is partially regulated by phosphorylation. As a first step to address the neuronal functions of Ack1, here we screened mouse brain samples to identify proteins that interact with this kinase. Using mass spectrometry analysis, ... [more]
Oncotarget Nov. 24, 2017; 8(60);101146-101157 [Pubmed: 29254152]
Throughput
- High Throughput
Curated By
- BioGRID