BAIT
TNK2
Ack, Ack-1, Ack1, Cdgip, Pyk1
tyrosine kinase, non-receptor, 2
GO Process (9)
GO Function (7)
GO Component (13)
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- regulation of cell proliferation [IBA]
- regulation of clathrin-mediated endocytosis [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DNMT3A
MmuIIIA
DNA methyltransferase 3A
GO Process (17)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- C-5 methylation of cytosine [IGI, ISO]
- DNA methylation [IDA, IGI, ISO]
- DNA methylation involved in embryo development [IMP]
- DNA methylation involved in gamete generation [IMP]
- DNA methylation on cytosine [ISO]
- DNA methylation on cytosine within a CG sequence [ISO]
- S-adenosylhomocysteine metabolic process [ISO]
- S-adenosylmethioninamine metabolic process [ISO]
- cellular response to amino acid stimulus [IDA]
- hypermethylation of CpG island [IDA]
- maintenance of DNA methylation [TAS]
- methylation [TAS]
- methylation-dependent chromatin silencing [IDA, IGI]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of cell death [ISO]
- regulation of gene expression by genetic imprinting [IDA, IMP]
- spermatogenesis [IMP]
Gene Ontology Molecular Function- DNA (cytosine-5-)-methyltransferase activity [IDA, IGI, ISO]
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [ISO]
- DNA binding [IDA, ISO]
- chromatin binding [IDA, ISO]
- identical protein binding [ISO]
- methyltransferase activity [TAS]
- protein binding [IPI]
- unmethylated CpG binding [ISO]
- DNA (cytosine-5-)-methyltransferase activity [IDA, IGI, ISO]
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [ISO]
- DNA binding [IDA, ISO]
- chromatin binding [IDA, ISO]
- identical protein binding [ISO]
- methyltransferase activity [TAS]
- protein binding [IPI]
- unmethylated CpG binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.
Ack1 (activated Cdc42-associated tyrosine kinase) is a non-receptor tyrosine kinase that is highly expressed in brain. This kinase contains several protein-protein interaction domains and its action is partially regulated by phosphorylation. As a first step to address the neuronal functions of Ack1, here we screened mouse brain samples to identify proteins that interact with this kinase. Using mass spectrometry analysis, ... [more]
Oncotarget Nov. 24, 2017; 8(60);101146-101157 [Pubmed: 29254152]
Throughput
- High Throughput
Curated By
- BioGRID