BAIT

FBXL17

FBXO13, Fbl17, Fbx13
F-box and leucine-rich repeat protein 17
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

TMOD1

D9S57E, ETMOD, TMOD, RP11-244N9.1
tropomodulin 1
GO Process (4)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.

Mason B, Flach S, Teixeira FR, Manzano Garcia R, Rueda OM, Abraham JE, Caldas C, Edwards PAW, Laman H

In cancer, many genes are mutated by genome rearrangement, but our understanding of the functional consequences of this remains rudimentary. Here we report the F-box protein encoded by FBXL17 is disrupted in the region of the gene that encodes its substrate-binding leucine rich repeat (LRR) domain. Truncating Fbxl17 LRRs impaired its association with the other SCF holoenzyme subunits Skp1, Cul1 ... [more]

Cell. Mol. Life Sci. Jul. 01, 2020; 77(13);2605-2620 [Pubmed: 31560077]

Throughput

  • High Throughput

Curated By

  • BioGRID