BAIT

FBXL17

FBXO13, Fbl17, Fbx13
F-box and leucine-rich repeat protein 17
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

TMEM126A

OPA7
transmembrane protein 126A
GO Process (1)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.

Mason B, Flach S, Teixeira FR, Manzano Garcia R, Rueda OM, Abraham JE, Caldas C, Edwards PAW, Laman H

In cancer, many genes are mutated by genome rearrangement, but our understanding of the functional consequences of this remains rudimentary. Here we report the F-box protein encoded by FBXL17 is disrupted in the region of the gene that encodes its substrate-binding leucine rich repeat (LRR) domain. Truncating Fbxl17 LRRs impaired its association with the other SCF holoenzyme subunits Skp1, Cul1 ... [more]

Cell. Mol. Life Sci. Jul. 01, 2020; 77(13);2605-2620 [Pubmed: 31560077]

Throughput

  • High Throughput

Curated By

  • BioGRID