SPI1
Gene Ontology Biological Process
- histone H3 acetylation [IMP]
- hypermethylation of CpG island [IDA]
- negative regulation of gene expression, epigenetic [IDA]
- negative regulation of histone H4 acetylation [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of erythrocyte differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [IBA]
Gene Ontology Molecular Function- NFAT protein binding [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding [ISS]
- core promoter binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA]
- NFAT protein binding [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- RNA polymerase II transcription factor binding [ISS]
- core promoter binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
ETV1
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [TAS]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains.
The ets genes family encodes a group of proteins which function as transcription factors under physiological conditions. We report here that the Erg proteins, members of the Ets family, form homo and heterodimeric complexes in vitro. We demonstrate that the Ergp55 protein isoform forms dimers with itself and with the two other isoforms, Ergp49 and Ergp38. Using a set of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID