BAIT
ADRBK1
BARK1, BETA-ARK1, GRK2
adrenergic, beta, receptor kinase 1
GO Process (15)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- activation of phospholipase C activity [TAS]
- cardiac muscle contraction [IMP]
- desensitization of G-protein coupled receptor protein signaling pathway [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of striated muscle contraction [IMP]
- negative regulation of the force of heart contraction by chemical signal [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [ISS]
- positive regulation of catecholamine secretion [ISS]
- receptor internalization [IDA]
- signal transduction [TAS]
- tachykinin receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
RHO
CSNBAD1, OPN2, RP4
rhodopsin
GO Process (5)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interaction between the conserved region in the C-terminal domain of GRK2 and rhodopsin is necessary for GRK2 to catalyze receptor phosphorylation.
The C-terminal domain of G protein-coupled receptor kinases (GRKs) consists of a conserved region and a variable region, and the variable region has been shown to direct the membrane translocation of cytosolic enzymes. The present work has revealed that the C-terminal domain may also be involved in kinase-receptor interaction that is primarily mediated by the conserved region. Truncation of the ... [more]
J. Biol. Chem. Mar. 24, 2000; 275(12);8469-74 [Pubmed: 10722682]
Throughput
- Low Throughput
Curated By
- BioGRID