F2
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- cell surface receptor signaling pathway [IDA]
- cellular protein metabolic process [TAS]
- cytosolic calcium ion homeostasis [IDA]
- fibrinolysis [IDA]
- leukocyte migration [TAS]
- multicellular organismal development [TAS]
- negative regulation of astrocyte differentiation [IDA]
- negative regulation of fibrinolysis [TAS]
- negative regulation of platelet activation [TAS]
- negative regulation of proteolysis [IDA]
- peptidyl-glutamic acid carboxylation [TAS]
- platelet activation [IDA, TAS]
- positive regulation of blood coagulation [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- post-translational protein modification [TAS]
- proteolysis [TAS]
- regulation of blood coagulation [TAS]
- response to wounding [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FGA
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, common pathway [IMP]
- cell-matrix adhesion [IDA]
- cellular protein complex assembly [IDA]
- extracellular matrix organization [TAS]
- negative regulation of blood coagulation, common pathway [TAS]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- platelet activation [TAS]
- platelet aggregation [IDA, IMP]
- platelet degranulation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of exocytosis [IDA]
- positive regulation of heterotypic cell-cell adhesion [IDA]
- positive regulation of peptide hormone secretion [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of substrate adhesion-dependent cell spreading [NAS]
- positive regulation of vasoconstriction [IDA]
- protein polymerization [IDA]
- response to calcium ion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
The interaction of thrombin with fibrinogen. A structural basis for its specificity.
The structure of the ternary complex of human alpha-thrombin with a covalently bound analogue of fibrinopeptide A and a C-terminal hirudin peptide has been determined by X-ray diffraction methods at 0.25 nm resolution. Fibrinopeptide A folds in a compact manner, bringing together hydrophobic residues that slot into the apolar binding site of human alpha-thrombin. Fibrinogen residue Phe8 occupies the aryl-binding ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FGA F2 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | High | - | BioGRID | 1504708 |
Curated By
- BioGRID