TP63
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IBA]
- cellular response to UV [IBA]
- central nervous system development [IGI]
- epidermis morphogenesis [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- mitotic G1 DNA damage checkpoint [IBA]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- negative regulation of transcription, DNA-templated [IDA]
- regulation of neuron apoptotic process [IBA]
- response to X-ray [IBA]
- response to gamma radiation [IBA]
Gene Ontology Molecular Function
CRBN
Gene Ontology Biological Process
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
p63 is a cereblon substrate involved in thalidomide teratogenicity.
Cereblon (CRBN) is a primary target of thalidomide and mediates its multiple pharmacological activities, including teratogenic and antimyeloma activities. CRBN functions as a substrate receptor of the E3 ubiquitin ligase CRL4, whose substrate specificity is modulated by thalidomide and its analogs. Although a number of CRL4CRBN substrates have recently been identified, the substrate involved in thalidomide teratogenicity is unclear. Here ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID