TRIB3
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- cellular response to insulin stimulus [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IDA]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of fatty acid biosynthetic process [ISS]
- negative regulation of protein kinase activity [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of protein binding [ISS]
- positive regulation of ubiquitin-protein transferase activity [ISS]
- regulation of MAP kinase activity [IDA]
- regulation of glucose transport [ISS]
- response to endoplasmic reticulum stress [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TWIST1
Gene Ontology Biological Process
- aortic valve morphogenesis [IMP]
- cell proliferation involved in heart valve development [IMP]
- cellular response to hypoxia [IMP]
- cranial suture morphogenesis [TAS]
- embryonic camera-type eye formation [IMP]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic digit morphogenesis [TAS]
- eyelid development in camera-type eye [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- negative regulation of cellular senescence [IMP]
- negative regulation of double-strand break repair [IMP]
- negative regulation of histone phosphorylation [IMP]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of phosphatidylinositol 3-kinase signaling [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- ossification [TAS]
- outer ear morphogenesis [TAS]
- positive regulation of angiogenesis [NAS]
- positive regulation of cell motility [IMP, NAS]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of fatty acid beta-oxidation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of interleukin-6 secretion [IMP]
- positive regulation of monocyte chemotactic protein-1 production [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription regulatory region DNA binding [IMP]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of bone mineralization [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
TRIB3 Stabilizes High TWIST1 Expression to Promote Rapid APL Progression and ATRA Resistance.
The resistance to differentiation therapy and early death caused by fatal bleeding endangers the health of a significant proportion of patients with acute promyelocytic leukemia (APL). This study aims to investigate the molecular mechanisms of all-trans retinoic acid (ATRA) resistance and uncover new potential therapeutic strategies to block the rapid progression of early death.The important role of TWIST1 in APL ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TWIST1 TRIB3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TRIB3 TWIST1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID