ZPR1
Gene Ontology Biological Process
- Cajal body organization [IMP, ISO]
- DNA endoreduplication [IMP]
- apoptotic process involved in development [IMP]
- axon development [IMP, ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- inner cell mass cell proliferation [IMP]
- microtubule cytoskeleton organization [IMP]
- negative regulation of motor neuron apoptotic process [IMP]
- positive regulation of RNA splicing [ISO]
- positive regulation of gene expression [IMP, ISO]
- positive regulation of growth [IMP]
- positive regulation of protein import into nucleus [IMP, ISO]
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle [ISO]
- pre-mRNA catabolic process [ISO]
- regulation of myelination [IMP]
- spinal cord development [IMP]
- trophectodermal cell proliferation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EEF1A1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells.
The zinc finger protein ZPR1 is present in the cytoplasm of quiescent mammalian cells and translocates to the nucleus upon treatment with mitogens, including epidermal growth factor (EGF). Homologues of ZPR1 were identified in yeast and mammals. These ZPR1 proteins bind to eukaryotic translation elongation factor-1alpha (eEF-1alpha). Studies of mammalian cells demonstrated that EGF treatment induces the interaction of ZPR1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID