BAIT
PAX8
paired box 8
GO Process (33)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- branching involved in ureteric bud morphogenesis [IEP]
- cellular response to gonadotropin stimulus [IDA]
- central nervous system development [IEP]
- inner ear morphogenesis [ISS]
- kidney development [IEP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IEP]
- mesonephros development [ISS]
- metanephric S-shaped body morphogenesis [IEP]
- metanephric comma-shaped body morphogenesis [IEP]
- metanephric distal convoluted tubule development [ISS]
- metanephric epithelium development [IEP]
- metanephric nephron tubule formation [ISS]
- negative regulation of apoptotic process involved in metanephric collecting duct development [ISS]
- negative regulation of apoptotic process involved in metanephric nephron tubule development [ISS]
- negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis [ISS]
- negative regulation of mesenchymal cell apoptotic process involved in metanephros development [ISS]
- otic vesicle development [IEP]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [ISS]
- positive regulation of metanephric DCT cell differentiation [ISS]
- positive regulation of thyroid hormone generation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- pronephric field specification [ISS]
- pronephros development [ISS]
- regulation of apoptotic process [ISS]
- regulation of metanephric nephron tubule epithelial cell differentiation [ISS]
- regulation of thyroid-stimulating hormone secretion [IMP]
- thyroid gland development [IEP, IMP]
- thyroid-stimulating hormone signaling pathway [TAS]
- transcription, DNA-templated [IDA]
- urogenital system development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA, ISS]
- nucleus [IDA]
Homo sapiens
PREY
PARP1
ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1, RP11-125A15.2
poly (ADP-ribose) polymerase 1
GO Process (12)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular response to insulin stimulus [IDA]
- double-strand break repair [IMP]
- gene expression [TAS]
- macrophage differentiation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- protein ADP-ribosylation [IDA]
- protein poly-ADP-ribosylation [IDA]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HBx regulates transcription factor PAX8 stabilization to promote the progression of hepatocellular carcinoma.
Transcription factor PAX8 expression is upregulated in several types of cancers. However, little is known about the function of PAX8 in the progression of hepatoma and its regulatory mechanisms. Here, we show that PAX8 silencing inhibits the proliferation and clonogenicity of hepatoma cells and its growth in vivo. The HBV X protein (HBx) does not directly interacts, but stabilizes PAX8 ... [more]
Oncogene Dec. 01, 2018; 38(40);6696-6710 [Pubmed: 31391550]
Throughput
- High Throughput
Curated By
- BioGRID