BAIT

HCVGP1

polyprotein
GO Process (0)
GO Function (0)
GO Component (0)
Hepatitus C Virus
PREY

EIF2A

EIF-2A, MST089, MSTP004, MSTP089, CDA02
eukaryotic translation initiation factor 2A, 65kDa
GO Process (2)
GO Function (4)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.

Li Y, Wang L, Rivera-Serrano EE, Chen X, Lemon SM

The liver-specific microRNA, miR-122, is an essential host factor for replication of the hepatitis C virus (HCV). miR-122 stabilizes the positive-strand HCV RNA genome and promotes its synthesis by binding two sites (S1 and S2) near its 5' end in association with Ago2. Ago2 is essential for both host factor activities, but whether other host proteins are involved is unknown. ... [more]

Nucleic Acids Res. Dec. 09, 2018; 47(12);6411-6424 [Pubmed: 30997501]

Throughput

  • High Throughput

Curated By

  • BioGRID