IGF1R
Gene Ontology Biological Process
- axonogenesis [IMP]
- brain development [ISO]
- epidermis development [ISO]
- establishment of cell polarity [IMP]
- exocrine pancreas development [ISO]
- immune response [ISO]
- inactivation of MAPKK activity [ISO, ISS]
- insulin-like growth factor receptor signaling pathway [ISO, ISS]
- male sex determination [ISO]
- mammary gland development [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of muscle cell apoptotic process [IMP]
- negative regulation of protein kinase B signaling [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- neuron projection development [IDA]
- organ morphogenesis [ISO]
- peptidyl-tyrosine autophosphorylation [ISO]
- phosphatidylinositol-mediated signaling [ISO]
- positive regulation of DNA metabolic process [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cytokinesis [IMP]
- positive regulation of mitosis [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of steroid hormone biosynthetic process [IMP]
- prostate gland epithelium morphogenesis [ISO]
- protein autophosphorylation [ISO, ISS]
- protein heterooligomerization [IDA]
- protein phosphorylation [ISO]
- protein tetramerization [ISO, ISS]
- regulation of JNK cascade [ISO, ISS]
- response to vitamin E [IEP]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [IPI]
- identical protein binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [IPI, ISO, ISS]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor binding [ISO, ISS, TAS]
- insulin-like growth factor-activated receptor activity [ISO, ISS, TAS]
- phosphatidylinositol 3-kinase binding [ISO, ISS]
- protein tyrosine kinase activity [ISO, ISS]
- G-protein alpha-subunit binding [IPI]
- identical protein binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [IPI, ISO, ISS]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor binding [ISO, ISS, TAS]
- insulin-like growth factor-activated receptor activity [ISO, ISS, TAS]
- phosphatidylinositol 3-kinase binding [ISO, ISS]
- protein tyrosine kinase activity [ISO, ISS]
Gene Ontology Cellular Component
EHD1
Gene Ontology Biological Process
- cellular response to nerve growth factor stimulus [IDA]
- cholesterol homeostasis [ISO]
- endocytic recycling [ISO, ISS]
- endocytosis [ISO, ISS]
- endosomal transport [ISO]
- intracellular protein transport [ISO, ISS]
- low-density lipoprotein particle clearance [ISO]
- neuron projection development [IMP]
- positive regulation of cholesterol storage [ISO]
- positive regulation of endocytic recycling [ISO, ISS]
- positive regulation of myoblast fusion [ISO, ISS]
- protein homooligomerization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- early endosome [ISO]
- early endosome membrane [ISO, ISS]
- endocytic vesicle [ISO]
- endosome [ISO]
- endosome membrane [IDA]
- extracellular vesicular exosome [ISO]
- lipid particle [ISO]
- membrane [ISO]
- myelin sheath [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO, ISS]
- platelet dense tubular network membrane [ISO]
- recycling endosome membrane [ISO, ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.
Ligand-induced receptor-mediated endocytosis plays a central role in regulating signaling conveyed by tyrosine kinase receptors. This process depends on the recruitment of the adaptor protein 2 (AP-2) complex, clathrin, dynamin, and other accessory proteins to the ligand-bound receptor. We show here that besides AP-2 and clathrin, two other proteins participate in the endocytic process of the insulin-like growth factor receptor ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID