Publication

Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway.

Li X, Sun Y, Huang S, Chen Y, Chen X, Li M, Si X, He X, Zheng H, Zhong L, Yang Y, Liao W, Liao Y, Chen G, Bin J

We previously found that loss of lncRNA-AZIN2 splice variant (AZIN2-sv) increases cardiomyocyte (CM) proliferation and attenuates adverse ventricular remodelling post-myocardial infarction (MI). However, whether inhibition of AZIN2-sv can simultaneously induce angiogenesis and thus improve prognosis after MI is unclear.We used in situ hybridization and quantitative PCR to determine AZIN2-sv expression in endothelial cells. Knockdown and overexpression were performed to detect ... [more]

Throughput

• High Throughput

Curated By

• BioGRID