IFNAR2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IFNA2
Gene Ontology Biological Process
- apoptotic process [TAS]
- blood coagulation [TAS]
- cell surface receptor signaling pathway [TAS]
- cell-cell signaling [TAS]
- cytokine-mediated signaling pathway [TAS]
- defense response to virus [IDA]
- inflammatory response [TAS]
- innate immune response [TAS]
- negative regulation of T cell differentiation [IDA]
- negative regulation of T-helper 2 cell cytokine production [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of interleukin-13 secretion [IDA]
- negative regulation of interleukin-5 secretion [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of viral entry into host cell [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2.
Type I interferons are cytokines which activate an anti-viral response by binding to two specific cell surface receptors, ifnar1 and ifnar2. Here, we report purification and refolding of the extracellular part of human ifnar2 (ifnar2-EC) expressed in Escherichia coli and its characterization with respect to its interaction with interferon alpha2 (IFNalpha2). The 25 kDa, non-glycosylated ifnar2-EC is a stable, fully ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IFNAR2 IFNA2 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID