CHRNE
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CHRNA1
Gene Ontology Biological Process
- cation transmembrane transport [IMP, ISS, TAS]
- ion transmembrane transport [TAS]
- muscle cell cellular homeostasis [IMP]
- musculoskeletal movement [IMP]
- neuromuscular junction development [IMP]
- neuromuscular process [IMP]
- neuromuscular synaptic transmission [IMP]
- neuron cellular homeostasis [IMP]
- neuronal action potential [IMP]
- regulation of membrane potential [IMP]
- signal transduction [TAS]
- skeletal muscle contraction [IMP]
- skeletal muscle tissue growth [IMP]
- synaptic transmission [TAS]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Extracellular domains mediating epsilon subunit interactions of muscle acetylcholine receptor.
Ligand-gated ion channels, a major class of cell-surface proteins, have a pseudosymmetric structure with five highly homologous subunits arranged around a central ion pore. The correct assembly of each channel, whose subunit composition varies with cell type and stage of development, requires specific recognition between the subunits. Assembly of the pentameric form of the acetylcholine receptor from adult muscle (AChR; ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID