BAIT

MIR15B

MIRN15B, hsa-mir-15b, miR-15b
microRNA 15b
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

SF3B2

Cus1, SAP145, SF3B145, SF3b1, SF3b150
splicing factor 3b, subunit 2, 145kDa
GO Process (4)
GO Function (2)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.

Treiber T, Treiber N, Plessmann U, Harlander S, Daiss JL, Eichner N, Lehmann G, Schall K, Urlaub H, Meister G

During microRNA (miRNA) biogenesis, two endonucleolytic reactions convert stem-loop-structured precursors into mature miRNAs. These processing steps can be posttranscriptionally regulated by RNA-binding proteins (RBPs). Here, we have used a proteomics-based pull-down approach to map and characterize the interactome of a multitude of pre-miRNAs. We identify ∼180 RBPs that interact specifically with distinct pre-miRNAs. For functional validation, we combined RNAi and CRISPR/Cas-mediated knockout ... [more]

Mol. Cell Apr. 20, 2017; 66(2);270-284.e13 [Pubmed: 28431233]

Throughput

  • High Throughput

Curated By

  • BioGRID