BAIT
MIR29A
MIRN29, MIRN29A, hsa-mir-29, hsa-mir-29a, miRNA29A
microRNA 29a
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
TRIM25
EFP, RNF147, Z147, ZNF147
tripartite motif containing 25
GO Process (7)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- innate immune response [IDA, TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- regulation of viral entry into host cell [IDA]
- regulation of viral release from host cell [IMP]
Gene Ontology Molecular Function
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.
During microRNA (miRNA) biogenesis, two endonucleolytic reactions convert stem-loop-structured precursors into mature miRNAs. These processing steps can be posttranscriptionally regulated by RNA-binding proteins (RBPs). Here, we have used a proteomics-based pull-down approach to map and characterize the interactome of a multitude of pre-miRNAs. We identify ∼180 RBPs that interact specifically with distinct pre-miRNAs. For functional validation, we combined RNAi and CRISPR/Cas-mediated knockout ... [more]
Mol. Cell Apr. 20, 2017; 66(2);270-284.e13 [Pubmed: 28431233]
Throughput
- High Throughput
Curated By
- BioGRID