BAIT
MIR29A
MIRN29, MIRN29A, hsa-mir-29, hsa-mir-29a, miRNA29A
microRNA 29a
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
UTP20
DRIM
UTP20, small subunit (SSU) processome component, homolog (yeast)
GO Process (6)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISS]
- endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISS]
- endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISS]
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IBA]
- negative regulation of cell proliferation [TAS]
- rRNA processing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-RNA
An interaction is detected between and protein and an RNA in vitro.
Publication
A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.
During microRNA (miRNA) biogenesis, two endonucleolytic reactions convert stem-loop-structured precursors into mature miRNAs. These processing steps can be posttranscriptionally regulated by RNA-binding proteins (RBPs). Here, we have used a proteomics-based pull-down approach to map and characterize the interactome of a multitude of pre-miRNAs. We identify ∼180 RBPs that interact specifically with distinct pre-miRNAs. For functional validation, we combined RNAi and CRISPR/Cas-mediated knockout ... [more]
Mol. Cell Apr. 20, 2017; 66(2);270-284.e13 [Pubmed: 28431233]
Throughput
- High Throughput
Curated By
- BioGRID