FGF1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- anatomical structure morphogenesis [TAS]
- branch elongation involved in ureteric bud branching [IDA]
- cellular response to heat [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- mesonephric epithelium development [IDA]
- multicellular organismal development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of angiogenesis [IDA]
- positive regulation of cell division [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IGI]
- positive regulation of cholesterol biosynthetic process [IDA]
- positive regulation of intracellular signal transduction [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPA9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin.
Fibroblast growth factor-1 (FGF-1), which lacks a signal peptide and is intracellularly localized as a result of endogenous expression or endocytosis, is thought to be involved in regulating cell growth and differentiation. In the study reported here, we purified proteins that bind intracellular FGF-1. Affinity adsorption was used to purify FGF-1-binding proteins from rat L6 cells expressing FGF-1. One of ... [more]
Throughput
- Low Throughput
Additional Notes
- microsequencing
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FGF1 HSPA9 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FGF1 HSPA9 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| FGF1 HSPA9 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID