ELANE
Gene Ontology Biological Process
- cellular calcium ion homeostasis [NAS]
- collagen catabolic process [TAS]
- defense response to bacterium [IDA]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of chemokine biosynthetic process [IDA]
- negative regulation of chemotaxis [NAS]
- negative regulation of inflammatory response [NAS]
- negative regulation of interleukin-8 biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of MAP kinase activity [NAS]
- positive regulation of interleukin-8 biosynthetic process [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- protein catabolic process [NAS]
- proteolysis [IDA]
- response to UV [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SERPINA3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.
Both human neutrophil elastase (HNE) and free chymotrypsin (Chtr) proteolyze Chtr within the complex that Chtr forms with antichymotrypsin (ACT). As free Chtr is stable both to self-digestion and to digestion by HNE, these results are indicative of a stability and/or conformational change in Chtr that accompanies complex formation. As determined by both N-terminal sequence analysis and matrix-assisted laser desorption ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID