CTNND1
Gene Ontology Biological Process
Gene Ontology Molecular Function
CDH3
Gene Ontology Biological Process
- adherens junction organization [TAS]
- canonical Wnt signaling pathway [IMP]
- cell adhesion [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- hair cycle process [IMP]
- keratinization [IMP]
- negative regulation of catagen [IMP]
- negative regulation of transforming growth factor beta2 production [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of insulin-like growth factor receptor signaling pathway [IMP]
- positive regulation of keratinocyte proliferation [IMP]
- positive regulation of melanin biosynthetic process [IMP]
- positive regulation of melanosome transport [IMP]
- positive regulation of monophenol monooxygenase activity [IMP]
- regulation of hair cycle by canonical Wnt signaling pathway [IMP]
- retina homeostasis [IMP]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts.
p120cas (CAS) is a tyrosine kinase substrate whose phosphorylation has been implicated in cell transformation by Src and in ligand-induced signaling through the EGF, PDGF, and CSF-1 receptors. More recently, CAS has been shown to associate with E-cadherin and its cofactors (catenins), molecules that are involved in cell adhesion. Although both CAS and beta-catenin contain armadillo repeat domains (Arm domains), ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDH3 CTNND1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID