KCNQ1
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [IMP]
- cardiac muscle contraction [IMP]
- cellular response to cAMP [IDA, IMP]
- cellular response to drug [IDA]
- cellular response to epinephrine stimulus [TAS]
- membrane repolarization during action potential [IDA]
- membrane repolarization during cardiac muscle cell action potential [IMP, TAS]
- positive regulation of potassium ion transmembrane transport [IDA]
- potassium ion export [IDA]
- potassium ion transmembrane transport [IDA]
- regulation of atrial cardiac muscle cell membrane repolarization [IMP]
- regulation of heart contraction [IC]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of membrane repolarization [IDA, IMP]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sensory perception of sound [TAS]
- synaptic transmission [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- calmodulin binding [IDA]
- delayed rectifier potassium channel activity [IDA]
- ion channel binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- protein phosphatase 1 binding [IDA]
- scaffold protein binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
- calmodulin binding [IDA]
- delayed rectifier potassium channel activity [IDA]
- ion channel binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- protein phosphatase 1 binding [IDA]
- scaffold protein binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [IMP]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
Gene Ontology Cellular Component
PRKACA
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- activation of phospholipase C activity [TAS]
- activation of protein kinase A activity [TAS]
- blood coagulation [TAS]
- calcium-mediated signaling using intracellular calcium source [TAS]
- carbohydrate metabolic process [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- cellular response to epinephrine stimulus [TAS]
- cellular response to glucagon stimulus [TAS]
- cellular response to glucose stimulus [IDA]
- cytosolic calcium ion homeostasis [TAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- innate immune response [TAS]
- intracellular signal transduction [TAS]
- mitotic cell cycle [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of cell cycle arrest [ISS]
- protein phosphorylation [NAS]
- regulation of cardiac muscle contraction [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [TAS]
- regulation of heart rate [TAS]
- regulation of insulin secretion [TAS]
- regulation of osteoblast differentiation [IDA]
- regulation of proteasomal protein catabolic process [IDA]
- regulation of protein binding [TAS]
- regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- regulation of tight junction assembly [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- sperm capacitation [ISS]
- transmembrane transport [TAS]
- triglyceride catabolic process [TAS]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel.
Sympathetic nervous system (SNS) regulation of cardiac action potential duration (APD) is mediated by beta adrenergic receptor (betaAR) activation, which increases the slow outward potassium ion current (IKS). Mutations in two human I(KS) channel subunits, hKCNQ1 and hKCNE1, prolong APD and cause inherited cardiac arrhythmias known as LQTS (long QT syndrome). We show that betaAR modulation of I(KS) requires targeting ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KCNQ1 PRKACA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID