BAIT
MAP2K1
CFC3, MAPKK1, MEK1, MKK1, PRKMK1
mitogen-activated protein kinase kinase 1
GO Process (36)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [IDA, TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- cell cycle arrest [IMP]
- cellular component movement [TAS]
- cellular senescence [IMP]
- chemotaxis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- negative regulation of cell proliferation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of gene expression [IMP]
- positive regulation of protein serine/threonine kinase activity [IDA]
- regulation of Golgi inheritance [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of stress-activated MAPK cascade [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FLNA
ABP-280, Dilp2, F730004A14Rik, Fln1, GENA 379, filamin-1, RP23-436K3.1
filamin, alpha
GO Process (19)
GO Function (16)
GO Component (18)
Gene Ontology Biological Process
- actin crosslink formation [ISO]
- actin cytoskeleton organization [IGI]
- actin cytoskeleton reorganization [ISO]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [ISO]
- cilium assembly [ISO]
- cytoplasmic sequestering of protein [ISO]
- early endosome to late endosome transport [IDA]
- epithelial to mesenchymal transition [IGI]
- establishment of protein localization [ISO]
- mRNA transcription from RNA polymerase II promoter [ISO]
- negative regulation of protein catabolic process [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- platelet aggregation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- protein localization to cell surface [ISO]
- protein stabilization [ISO]
- receptor clustering [ISO]
- spindle assembly involved in mitosis [ISO]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
- Fc-gamma receptor I complex binding [ISO]
- Rac GTPase binding [ISO]
- Ral GTPase binding [ISO]
- Rho GTPase binding [ISO]
- SMAD binding [ISO]
- actin binding [TAS]
- actin filament binding [ISO]
- glycoprotein binding [ISO]
- mu-type opioid receptor binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [IDA]
- signal transducer activity [ISO]
- small GTPase binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Myb complex [ISO]
- actin cytoskeleton [ISO]
- actin filament [ISO]
- actin filament bundle [IDA]
- apical dendrite [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendritic shaft [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- neuronal cell body [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- trans-Golgi network [IDA]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.
SEK-1, a dual specificity protein kinase that serves as one of the immediate upstream activators of the stress-activated protein kinases (SAPKs), associates specifically with the actin-binding protein, ABP-280, in vitro and in situ. SEK-1 binds to the carboxyl-terminal rod segment of ABP-280, upstream of the ABP carboxyl-terminal dimerization domain. Activation of SEK-1 in situ increases the SEK-1 activity bound to ... [more]
J. Biol. Chem. Jan. 31, 1997; 272(5);2620-8 [Pubmed: 9006895]
Throughput
- Low Throughput
Curated By
- BioGRID