NOS1
Gene Ontology Biological Process
- arginine catabolic process [ISO]
- behavioral response to cocaine [ISO]
- cellular response to epinephrine stimulus [ISO]
- cellular response to growth factor stimulus [IMP]
- cellular response to mechanical stimulus [ISO]
- exogenous drug catabolic process [IMP]
- multicellular organismal response to stress [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of blood pressure [IBA, ISO]
- negative regulation of calcium ion transport [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of heart contraction [ISO]
- negative regulation of hydrolase activity [IMP]
- negative regulation of insulin secretion [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of potassium ion transport [IMP]
- negative regulation of serotonin uptake [IDA]
- negative regulation of vasoconstriction [ISO]
- nitric oxide biosynthetic process [IDA, ISO]
- nitric oxide mediated signal transduction [IBA, ISO]
- oxidation-reduction process [IBA]
- peptidyl-cysteine S-nitrosylation [IDA, ISO]
- positive regulation of adrenergic receptor signaling pathway involved in heart process [IMP]
- positive regulation of guanylate cyclase activity [IBA]
- positive regulation of histone acetylation [IMP]
- positive regulation of long-term synaptic potentiation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of sodium ion transmembrane transport [ISO]
- positive regulation of the force of heart contraction [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of vasodilation [IBA, ISO]
- regulation of heart contraction [ISO]
- regulation of sensory perception of pain [ISO]
- regulation of sodium ion transport [IMP]
- response to estrogen [ISO]
- response to heat [ISO]
- response to peptide hormone [ISO]
- striated muscle contraction [IMP]
Gene Ontology Molecular Function- ATPase binding [ISO]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- cadmium ion binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- heme binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- scaffold protein binding [ISO]
- sodium channel regulator activity [ISO]
- ATPase binding [ISO]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA]
- cadmium ion binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- heme binding [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase activity [IDA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- scaffold protein binding [ISO]
- sodium channel regulator activity [ISO]
Gene Ontology Cellular Component
- azurophil granule [ISO]
- cytoplasm [ISO]
- cytoskeleton [IDA]
- cytosol [IBA, ISO]
- dendrite [ISO]
- membrane [ISO]
- membrane raft [IDA]
- mitochondrial outer membrane [ISO]
- mitochondrion [ISO]
- nuclear membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- photoreceptor inner segment [ISO]
- plasma membrane [ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- sarcoplasmic reticulum [ISO]
- synapse [IDA, ISO]
- vesicle membrane [ISO]
ATP2B1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical part of cell [ISO]
- apical plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cytoplasmic side of plasma membrane [ISO]
- dendrite membrane [ISO]
- dendritic spine membrane [ISO]
- extracellular vesicular exosome [ISO]
- integral component of plasma membrane [TAS]
- membrane [ISO]
- membrane raft [ISO]
- neuronal cell body membrane [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complex.
The main role of the plasma membrane Ca2+/calmodulin-dependent ATPase (PMCA) is in the removal of Ca2+ from the cytosol. Recently, we and others have suggested a new function for PMCA as a modulator of signal transduction pathways. This paper shows the physical interaction between PMCA (isoforms 1 and 4) and alpha-1 syntrophin and proposes a ternary complex of interaction between ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID