BAIT
HPD
4-HPPD, 4HPPD, GLOD3, HPPDASE, PPD
4-hydroxyphenylpyruvate dioxygenase
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARFGEF2
BIG2, PVNH2, dJ1164I10.1
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
GO Process (8)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- Golgi to plasma membrane transport [IMP]
- endomembrane system organization [IMP]
- endosome organization [IMP]
- intracellular signal transduction [IDA]
- positive regulation of GTPase activity [IBA, IDA]
- positive regulation of tumor necrosis factor production [IMP]
- receptor recycling [IDA]
- vesicle-mediated transport [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage.
Decreased expression of 4-hydroxyphenylpyruvic acid dioxygenase (HPD), a key enzyme for tyrosine metabolism, is a cause of human tyrosinemia. However, the regulation of HPD expression remains largely unknown. Here, we demonstrate that molecular chaperone TTC36, which is highly expressed in liver, is associated with HPD and reduces the binding of protein kinase STK33 to HPD, thereby inhibiting STK33-mediated HPD T382 ... [more]
Nat Commun Dec. 19, 2018; 10(1);4266 [Pubmed: 31537781]
Throughput
- High Throughput
Curated By
- BioGRID