BAIT
GRIN2A
GluN2A, NMDAR2A, NR2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GO Process (62)
GO Function (19)
GO Component (13)
Gene Ontology Biological Process
- action potential [IMP]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transmembrane transport [IDA]
- cation transport [IDA]
- cellular response to amino acid stimulus [IMP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to lipid [IEP]
- cellular response to magnesium ion [IEP]
- cellular response to manganese ion [IEP]
- cellular response to zinc ion [IMP]
- cerebral cortex development [IEP]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- directional locomotion [ISO]
- dopamine metabolic process [ISO]
- hippocampus development [IEP]
- ion transmembrane transport [IMP, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [ISO]
- locomotion [ISO]
- memory [IDA, ISO]
- negative regulation of protein catabolic process [ISO]
- neurogenesis [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- protein localization [ISO]
- protein tetramerization [IDA]
- regulation of excitatory postsynaptic membrane potential [IMP, ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [ISO]
- regulation of postsynaptic membrane potential [ISO]
- regulation of sensory perception of pain [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of synaptic transmission [ISO]
- response to amine [IEP]
- response to ammonium ion [IEP]
- response to amphetamine [ISO]
- response to calcium ion [IEP]
- response to carbohydrate [IEP]
- response to cocaine [IEP]
- response to drug [IEP, ISO]
- response to ethanol [IEP, ISO]
- response to fungicide [IEP]
- response to light stimulus [IEP]
- response to manganese ion [IEP]
- response to methylmercury [IEP]
- response to organic cyclic compound [IEP]
- response to other organism [IEP]
- response to wounding [ISO]
- rhythmic process [IDA]
- sensory perception of pain [ISO]
- serotonin metabolic process [ISO]
- sleep [ISO]
- spinal cord development [IEP]
- startle response [ISO]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [IBA]
- visual learning [ISO]
Gene Ontology Molecular Function- ATPase binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- calcium channel activity [ISO]
- cation channel activity [IDA, ISO]
- cell adhesion molecule binding [IPI]
- extracellular-glutamate-gated ion channel activity [IMP]
- glutamate binding [IDA, IMP]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA, IMP]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- zinc ion binding [IDA, ISS]
- ATPase binding [IPI]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IMP, ISO]
- calcium channel activity [ISO]
- cation channel activity [IDA, ISO]
- cell adhesion molecule binding [IPI]
- extracellular-glutamate-gated ion channel activity [IMP]
- glutamate binding [IDA, IMP]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor activity [IDA, IMP]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [IPI]
- voltage-gated cation channel activity [IMP]
- zinc ion binding [IDA, ISS]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO]
- cell surface [ISO]
- dendritic spine [IDA]
- endoplasmic reticulum [ISO]
- membrane [ISO]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- presynaptic membrane [IDA, ISO]
- synapse [ISO, TAS]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
Rattus norvegicus
PREY
CTNNB1
Catnb
catenin (cadherin associated protein), beta 1
GO Process (159)
GO Function (26)
GO Component (40)
Gene Ontology Biological Process
- Schwann cell proliferation [IMP]
- T cell differentiation [ISO]
- T cell differentiation in thymus [ISO]
- Wnt signaling pathway [ISO, ISS]
- adherens junction assembly [ISO, ISS]
- adherens junction organization [ISO]
- anterior/posterior axis specification [ISO]
- bone resorption [ISO]
- branching involved in ureteric bud morphogenesis [ISO]
- canonical Wnt signaling pathway [ISO, ISS]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [ISO]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [ISO]
- canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition [ISO, ISS]
- cell adhesion [ISO, ISS]
- cell differentiation [ISO]
- cell fate determination [ISO]
- cell fate specification [ISO]
- cell maturation [ISO]
- cell morphogenesis involved in differentiation [ISO]
- cell proliferation [ISO]
- cell-matrix adhesion [ISO]
- cellular process [ISO]
- cellular protein localization [ISO]
- cellular response to growth factor stimulus [ISO, ISS]
- cellular response to indole-3-methanol [ISO, ISS]
- cellular response to insulin-like growth factor stimulus [IEP, IMP]
- cellular response to mechanical stimulus [IDA]
- cellular response to organic cyclic compound [ISO]
- central nervous system vasculogenesis [ISO]
- chromatin-mediated maintenance of transcription [ISO]
- dorsal/ventral axis specification [ISO]
- dorsal/ventral pattern formation [ISO]
- ectoderm development [ISO]
- embryonic axis specification [ISO]
- embryonic digit morphogenesis [ISO]
- embryonic foregut morphogenesis [ISO]
- embryonic forelimb morphogenesis [ISO]
- embryonic heart tube development [ISO]
- embryonic hindlimb morphogenesis [ISO]
- embryonic skeletal limb joint morphogenesis [ISO]
- endoderm formation [ISO]
- endodermal cell fate commitment [ISO]
- endothelial tube morphogenesis [ISO, ISS]
- epithelial cell differentiation involved in prostate gland development [ISO]
- epithelial tube branching involved in lung morphogenesis [ISO]
- forebrain development [ISO]
- fungiform papilla formation [ISO]
- gastrulation with mouth forming second [ISO]
- genitalia morphogenesis [ISO]
- glial cell fate determination [ISO]
- hair cycle process [ISO]
- hair follicle morphogenesis [ISO]
- hair follicle placode formation [ISO]
- heart development [ISO]
- hemopoiesis [ISO]
- in utero embryonic development [ISO]
- kidney development [ISO]
- layer formation in cerebral cortex [ISO]
- lens morphogenesis in camera-type eye [ISO]
- limb development [ISO]
- liver development [IEP]
- lung cell differentiation [ISO]
- lung development [ISO]
- lung induction [ISO]
- lung-associated mesenchyme development [ISO]
- male genitalia development [ISO]
- mesenchymal cell proliferation involved in lung development [ISO]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [ISO]
- metanephros morphogenesis [ISO]
- midgut development [IEP]
- morphogenesis of embryonic epithelium [ISO]
- myoblast differentiation [IEP]
- negative regulation of apoptotic signaling pathway [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of chondrocyte differentiation [ISO]
- negative regulation of mitotic cell cycle, embryonic [ISO, ISS]
- negative regulation of neuron death [ISO]
- negative regulation of oligodendrocyte differentiation [ISO]
- negative regulation of osteoclast differentiation [ISO]
- negative regulation of protein sumoylation [ISO, ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO, ISS]
- nephron tubule formation [ISO]
- neural plate development [ISO]
- neuron migration [ISO]
- odontogenesis of dentin-containing tooth [IEP, ISO]
- oocyte development [ISO]
- organ development [ISO]
- osteoclast differentiation [ISO]
- oviduct development [ISO]
- pancreas development [ISO]
- patterning of blood vessels [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of branching involved in lung morphogenesis [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of determination of dorsal identity [ISO]
- positive regulation of endothelial cell differentiation [ISO]
- positive regulation of epithelial cell differentiation [ISO]
- positive regulation of epithelial cell proliferation involved in prostate gland development [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of fibroblast growth factor receptor signaling pathway [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of heparan sulfate proteoglycan biosynthetic process [ISO, ISS]
- positive regulation of mesenchymal cell proliferation [ISO]
- positive regulation of neuroblast proliferation [ISO, ISS]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of telomerase activity [ISO]
- positive regulation of telomere maintenance via telomerase [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- protein heterooligomerization [IPI]
- protein localization to cell surface [ISO, ISS]
- proximal/distal pattern formation [ISO]
- regulation of T cell proliferation [ISO]
- regulation of apoptotic process [ISO]
- regulation of calcium ion import [ISO, ISS]
- regulation of cell differentiation [ISO]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [ISO]
- regulation of centriole-centriole cohesion [ISO, ISS]
- regulation of centromeric sister chromatid cohesion [ISO, ISS]
- regulation of epithelial cell differentiation [ISO]
- regulation of gene expression [ISO]
- regulation of myelination [ISO]
- regulation of nephron tubule epithelial cell differentiation [ISO]
- regulation of osteoblast differentiation [ISO]
- regulation of osteoclast differentiation [ISO]
- regulation of protein localization to cell surface [ISO, ISS]
- regulation of secondary heart field cardioblast proliferation [ISO]
- regulation of smooth muscle cell proliferation [ISO, ISS]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [ISO]
- renal inner medulla development [ISO]
- renal outer medulla development [ISO]
- renal system development [ISO]
- renal vesicle formation [ISO]
- response to cadmium ion [IEP]
- response to cytokine [IDA]
- response to drug [ISO]
- response to estradiol [ISO, ISS]
- response to estrogen [IDA]
- response to hormone [IEP]
- response to organic cyclic compound [IEP]
- single organismal cell-cell adhesion [IDA, ISO, ISS, TAS]
- skeletal system development [ISO]
- skin development [ISO]
- smooth muscle cell differentiation [ISO]
- sympathetic ganglion development [ISO, ISS]
- synapse organization [ISO]
- synaptic transmission [ISO]
- synaptic vesicle transport [ISO]
- thymus development [ISO]
- trachea formation [ISO]
- trachea morphogenesis [ISO]
- vasculature development [ISO]
- vasculogenesis [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- SMAD binding [ISO]
- alpha-catenin binding [IBA, ISO]
- cadherin binding [IDA, IPI, ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- euchromatin binding [ISO]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- kinase binding [ISO]
- nitric-oxide synthase binding [IPI]
- nuclear hormone receptor binding [IBA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein phosphatase binding [IBA, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [IBA, ISO, ISS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO, ISS]
- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- SMAD binding [ISO]
- alpha-catenin binding [IBA, ISO]
- cadherin binding [IDA, IPI, ISO]
- chromatin binding [ISO]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- euchromatin binding [ISO]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- kinase binding [ISO]
- nitric-oxide synthase binding [IPI]
- nuclear hormone receptor binding [IBA, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein phosphatase binding [IBA, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [IBA, ISO, ISS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO, ISS]
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [ISO]
- Z disc [ISO]
- adherens junction [ISO]
- apical junction complex [ISO]
- apical part of cell [ISO]
- basolateral plasma membrane [ISO]
- beta-catenin destruction complex [ISO, ISS]
- beta-catenin-TCF7L2 complex [ISO, ISS]
- catenin complex [IBA, ISO, ISS]
- catenin-TCF7L2 complex [ISO]
- cell [ISO]
- cell cortex [ISO, ISS]
- cell junction [ISO, ISS]
- cell periphery [ISO, ISS]
- cell projection membrane [ISO]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [ISO, ISS]
- centrosome [ISO, ISS]
- cytoplasm [ISO, ISS, TAS]
- cytosol [IDA, ISO]
- dendritic shaft [IDA]
- extracellular vesicular exosome [ISO]
- fascia adherens [ISO]
- focal adhesion [ISO]
- intercalated disc [ISO]
- lamellipodium [ISO]
- lateral plasma membrane [ISO]
- membrane [IDA, ISO]
- microvillus membrane [ISO]
- neuron projection [IDA]
- nuclear euchromatin [ISO]
- nuclear transcription factor complex [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA, ISO, ISS]
- plasma membrane [ISO, ISS]
- protein complex [IDA]
- protein-DNA complex [ISO, ISS]
- synapse [IDA]
- tight junction [ISO]
- transcription factor complex [ISO, ISS]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
NMDA di-heteromeric receptor populations and associated proteins in rat hippocampus.
Subunit composition of NMDA receptors (NMDARs) determines a range of physiological properties, downstream signaling effects, and binding partners. Differential localization of NR2A- or NR2B-containing NMDARs within the neuron and subunit-specific protein associations may explain differences in NR2A and NR2B contributions to synaptic plasticity and excitotoxic cell death. This question is complicated by the existence of tri-heteromeric complexes (NR1/NR2A/NR2B). To date, ... [more]
J. Neurosci. Aug. 01, 2007; 27(31);8334-43 [Pubmed: 17670980]
Throughput
- Low Throughput
Curated By
- BioGRID