NOS1
Gene Ontology Biological Process
- aging [IEP]
- arginine catabolic process [IDA]
- behavioral response to cocaine [IMP]
- cellular response to epinephrine stimulus [IMP]
- cellular response to growth factor stimulus [ISO]
- cellular response to mechanical stimulus [IMP]
- exogenous drug catabolic process [ISO]
- female pregnancy [IEP]
- multicellular organismal response to stress [ISO]
- muscle contraction [IBA]
- negative regulation of apoptotic process [IMP]
- negative regulation of blood pressure [IMP]
- negative regulation of calcium ion transport [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of cytosolic calcium ion concentration [IMP]
- negative regulation of heart contraction [IMP]
- negative regulation of hydrolase activity [ISO]
- negative regulation of insulin secretion [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- negative regulation of potassium ion transport [ISO]
- negative regulation of serotonin uptake [ISO]
- negative regulation of vasoconstriction [IMP]
- nitric oxide biosynthetic process [IDA, ISO]
- nitric oxide mediated signal transduction [IBA, IMP]
- peptidyl-cysteine S-nitrosylation [IDA, ISO]
- positive regulation of adrenergic receptor signaling pathway involved in heart process [ISO]
- positive regulation of guanylate cyclase activity [IBA]
- positive regulation of histone acetylation [ISO]
- positive regulation of long-term synaptic potentiation [IMP]
- positive regulation of neuron death [IMP]
- positive regulation of sodium ion transmembrane transport [IMP]
- positive regulation of the force of heart contraction [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of vasodilation [IMP, ISO]
- regulation of heart contraction [IMP]
- regulation of sensory perception of pain [IMP]
- regulation of sodium ion transport [ISO]
- response to activity [IEP]
- response to estrogen [IDA]
- response to ethanol [IEP]
- response to heat [IEP, ISO]
- response to hypoxia [IEP, ISO]
- response to lead ion [IEP]
- response to lipopolysaccharide [IEP]
- response to nicotine [IEP]
- response to nitric oxide [IEP]
- response to nutrient levels [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IMP]
- response to vitamin E [IEP]
- striated muscle contraction [ISO]
Gene Ontology Molecular Function- ATPase binding [IPI]
- FMN binding [IDA, TAS]
- NADP binding [IDA, TAS]
- NADPH-hemoprotein reductase activity [IBA]
- amino acid binding [TAS]
- cadmium ion binding [IDA]
- calmodulin binding [IDA]
- enzyme binding [IPI]
- flavin adenine dinucleotide binding [IDA, TAS]
- heme binding [IDA, TAS]
- ion channel binding [IPI]
- nitric-oxide synthase activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- scaffold protein binding [IPI]
- sodium channel regulator activity [IMP]
- ATPase binding [IPI]
- FMN binding [IDA, TAS]
- NADP binding [IDA, TAS]
- NADPH-hemoprotein reductase activity [IBA]
- amino acid binding [TAS]
- cadmium ion binding [IDA]
- calmodulin binding [IDA]
- enzyme binding [IPI]
- flavin adenine dinucleotide binding [IDA, TAS]
- heme binding [IDA, TAS]
- ion channel binding [IPI]
- nitric-oxide synthase activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- scaffold protein binding [IPI]
- sodium channel regulator activity [IMP]
Gene Ontology Cellular Component
- azurophil granule [IDA]
- cytoplasm [IDA]
- cytoskeleton [ISO]
- cytosol [IDA]
- dendrite [IDA]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrial outer membrane [IDA]
- mitochondrion [IDA]
- nuclear membrane [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- photoreceptor inner segment [IDA]
- plasma membrane [IDA]
- postsynaptic density [IDA]
- protein complex [IDA]
- sarcolemma [IDA, ISO]
- sarcoplasmic reticulum [ISO]
- synapse [IDA, ISO]
- vesicle membrane [IDA]
GRIN1
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- associative learning [ISO]
- calcium ion homeostasis [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transport [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to manganese ion [IEP]
- cerebral cortex development [ISO]
- conditioned taste aversion [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [ISO, TAS]
- long-term memory [ISO]
- male mating behavior [ISO]
- memory [ISO]
- negative regulation of neuron apoptotic process [ISO]
- neuromuscular process [ISO]
- olfactory learning [ISO]
- pons maturation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- prepulse inhibition [ISO]
- propylene metabolic process [ISO]
- protein tetramerization [IDA]
- regulation of axonogenesis [ISO]
- regulation of cell communication [ISO]
- regulation of dendrite morphogenesis [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [ISO]
- regulation of neuron apoptotic process [ISO]
- regulation of neuronal synaptic plasticity [ISO]
- regulation of respiratory gaseous exchange [ISO]
- regulation of synapse assembly [ISO]
- regulation of synaptic plasticity [ISO]
- respiratory gaseous exchange [ISO]
- response to amine [IEP]
- response to amphetamine [ISO]
- response to calcium ion [IEP]
- response to ethanol [ISO]
- response to fungicide [IEP]
- response to morphine [ISO]
- response to organic cyclic compound [IEP]
- rhythmic process [IDA]
- sensory perception of pain [ISO]
- social behavior [ISO]
- startle response [ISO]
- suckling behavior [ISO]
- synaptic transmission, glutamatergic [IBA, ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO, TAS]
- cell [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- dendrite membrane [IDA]
- dendritic spine [IDA, ISO]
- endoplasmic reticulum [ISO]
- excitatory synapse [IDA]
- integral component of plasma membrane [ISO]
- membrane [ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- synapse [IDA, ISO]
- synaptic cleft [IDA]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
NMDA di-heteromeric receptor populations and associated proteins in rat hippocampus.
Subunit composition of NMDA receptors (NMDARs) determines a range of physiological properties, downstream signaling effects, and binding partners. Differential localization of NR2A- or NR2B-containing NMDARs within the neuron and subunit-specific protein associations may explain differences in NR2A and NR2B contributions to synaptic plasticity and excitotoxic cell death. This question is complicated by the existence of tri-heteromeric complexes (NR1/NR2A/NR2B). To date, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID