MDGA1
Gene Ontology Biological Process
Gene Ontology Cellular Component
NLGN2
Gene Ontology Biological Process
- cell-cell junction maintenance [NAS]
- gephyrin clustering [ISS]
- metabolic process [IBA]
- neuron cell-cell adhesion [IBA, ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of inhibitory postsynaptic membrane potential [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- postsynaptic density protein 95 clustering [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein localization to synapse [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of respiratory gaseous exchange by neurological system process [ISS]
- regulation of synaptic transmission [IBA, ISS]
- single organismal cell-cell adhesion [NAS]
- synapse assembly [IBA, ISS, NAS]
- synapse organization [ISS]
- terminal button organization [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.
The MAM domain-containing GPI anchor proteins MDGA1 and MDGA2 are Ig superfamily adhesion molecules composed of six IG domains, a fibronectin III domain, a MAM domain, and a GPI anchor. MDGAs contribute to the radial migration and positioning of a subset of cortical neurons during early neural development. However, MDGAs continue to be expressed in postnatal brain, and their functions ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID