EPHB1
Gene Ontology Biological Process
- angiogenesis [IDA]
- axon guidance [ISS]
- cell chemotaxis [IDA]
- cell-substrate adhesion [IDA]
- central nervous system projection neuron axonogenesis [ISS]
- dendritic spine development [ISS]
- dendritic spine morphogenesis [ISS]
- detection of temperature stimulus involved in sensory perception of pain [ISS]
- ephrin receptor signaling pathway [IDA]
- establishment of cell polarity [ISS]
- neural precursor cell proliferation [ISS]
- neurogenesis [ISS]
- positive regulation of synapse assembly [ISS]
- protein autophosphorylation [IDA]
- regulation of ERK1 and ERK2 cascade [IDA]
- regulation of JNK cascade [IDA]
- regulation of neuron death [IMP]
- retinal ganglion cell axon guidance [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ACP1
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.
Eph family receptor tyrosine kinases (including EphA3, EphB4) direct pathfinding of neurons within migratory fields of cells expressing gradients of their membrane-bound ligands. Others (EphB1 and EphA2) direct vascular network assembly, affecting endothelial migration, capillary morphogenesis, and angiogenesis. To explore how ephrins could provide positional labels for cell targeting, we tested whether endogenous endothelial and P19 cell EphB1 (ELK) and ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
EPHB1 ACP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID