PSEN2
Gene Ontology Biological Process
- Notch receptor processing [IBA, TAS]
- Notch signaling pathway [TAS]
- amyloid precursor protein catabolic process [IBA, TAS]
- apoptotic signaling pathway [TAS]
- beta-amyloid metabolic process [IBA]
- calcium ion transport [IBA]
- membrane protein ectodomain proteolysis [IDA]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [IBA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of catalytic activity [IDA]
- protein processing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- Z disc [IBA]
- apical plasma membrane [IBA]
- axon [IBA]
- cell cortex [IBA]
- cell surface [IBA]
- centrosome [IDA]
- ciliary rootlet [IBA]
- dendritic shaft [IBA]
- endoplasmic reticulum [IDA]
- growth cone [IBA]
- integral component of plasma membrane [IDA]
- kinetochore [IDA]
- lysosomal membrane [IBA]
- membrane [IDA]
- membrane raft [IBA]
- mitochondrial inner membrane [IBA]
- neuromuscular junction [IBA]
- neuronal cell body [IBA]
- nuclear inner membrane [IDA]
- perinuclear region of cytoplasm [IBA]
- plasma membrane [TAS]
- protein complex [IDA]
ICAM5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.
The carboxyl terminus of presenilin 1 and 2 (PS1 and PS2) binds to the neuron-specific cell adhesion molecule telencephalin (TLN) in the brain. PS1 deficiency results in the abnormal accumulation of TLN in a yet unidentified intracellular compartment. The first transmembrane domain and carboxyl terminus of PS1 form a binding pocket with the transmembrane domain of TLN. Remarkably, APP binds ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID