USP15
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- histone H2B conserved C-terminal lysine deubiquitination [IDA]
- monoubiquitinated protein deubiquitination [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- pathway-restricted SMAD protein phosphorylation [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of proteasomal protein catabolic process [IBA]
- transforming growth factor beta receptor signaling pathway [IDA, IMP, TAS]
Gene Ontology Molecular Function
XDH
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of endothelial cell differentiation [IDA]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of protein kinase B signaling [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of vascular endothelial growth factor signaling pathway [IDA]
- negative regulation of vasculogenesis [IDA]
- nucleobase-containing small molecule metabolic process [TAS]
- positive regulation of p38MAPK cascade [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- purine nucleobase metabolic process [TAS]
- purine nucleotide catabolic process [TAS]
- small molecule metabolic process [TAS]
- xanthine catabolic process [IDA]
Gene Ontology Molecular Function- 2 iron, 2 sulfur cluster binding [IDA]
- flavin adenine dinucleotide binding [IDA]
- molybdopterin cofactor binding [IDA]
- oxidoreductase activity, acting on the aldehyde or oxo group of donors [IBA]
- protein homodimerization activity [IPI]
- xanthine dehydrogenase activity [IDA]
- xanthine oxidase activity [EXP, IDA]
- 2 iron, 2 sulfur cluster binding [IDA]
- flavin adenine dinucleotide binding [IDA]
- molybdopterin cofactor binding [IDA]
- oxidoreductase activity, acting on the aldehyde or oxo group of donors [IBA]
- protein homodimerization activity [IPI]
- xanthine dehydrogenase activity [IDA]
- xanthine oxidase activity [EXP, IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Loss of Xanthine Oxidoreductase Potentiates Propagation of Hepatocellular Carcinoma Stem Cells.
Liver cancer stem cells (CSCs) exist in the tumor environment and are critically involved in the initiation and progression of hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms of self-renewal and maintenance of liver CSCs remain poorly understood.We identified that xanthine oxidoreductase (XOR), which was expressed at low levels in human HCC samples and liver CSCs, restrained HCC formation and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| XDH USP15 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| XDH USP15 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID