PPP1R9B
Gene Ontology Biological Process
- actin cytoskeleton organization [TAS]
- actin filament organization [IPI]
- calcium-mediated signaling [IMP]
- cell migration [ISO]
- cellular response to morphine [IMP]
- dendrite development [IMP]
- filopodium assembly [ISO]
- negative regulation of cell growth [ISO]
- regulation of opioid receptor signaling pathway [IMP]
- regulation of protein phosphorylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ACTN2
Gene Ontology Biological Process
- focal adhesion assembly [ISO]
- microspike assembly [ISO]
- muscle contraction [IDA]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of potassium ion transport [ISO]
- negative regulation of protein localization to cell surface [ISO]
- positive regulation of potassium ion transmembrane transporter activity [ISO]
- positive regulation of potassium ion transport [ISO]
- positive regulation of receptor activity [IDA]
- protein homotetramerization [ISO]
- regulation of membrane potential [ISO]
- regulation of nucleic acid-templated transcription [IDA]
Gene Ontology Molecular Function- FATZ binding [ISO]
- LIM domain binding [IPI]
- actin filament binding [IDA, TAS]
- cytoskeletal protein binding [IDA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein dimerization activity [ISO]
- protein homodimerization activity [TAS]
- thyroid hormone receptor coactivator activity [IDA]
- titin Z domain binding [ISO]
- titin binding [ISO]
- FATZ binding [ISO]
- LIM domain binding [IPI]
- actin filament binding [IDA, TAS]
- cytoskeletal protein binding [IDA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein dimerization activity [ISO]
- protein homodimerization activity [TAS]
- thyroid hormone receptor coactivator activity [IDA]
- titin Z domain binding [ISO]
- titin binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.
Signaling changes that occur in the striatum following the loss of dopamine neurons in the Parkinson disease (PD) are poorly understood. While increases in the activity of kinases and decreases in the activity of phosphatases have been observed, the specific consequences of these changes are less well understood. Phosphatases, such as protein phosphatase 1 (PP1), are highly promiscuous and obtain ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPP1R9B ACTN2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| PPP1R9B ACTN2 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID