CD46
Gene Ontology Biological Process
- T cell mediated immunity [IMP]
- adaptive immune response [IC]
- innate immune response [TAS]
- interleukin-10 production [IDA]
- negative regulation of gene expression [IDA]
- positive regulation of T cell proliferation [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of memory T cell differentiation [IDA]
- positive regulation of regulatory T cell differentiation [IDA]
- positive regulation of transforming growth factor beta production [IDA]
- regulation of Notch signaling pathway [IDA]
- regulation of complement activation [TAS]
- sequestering of extracellular ligand from receptor [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CD9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans.
The tetraspans associate with a large number of surface molecules, including a subset of beta1 integrins and, indirectly through CD19, with the complement receptor CD21. To further characterize the tetraspan complexes we have raised and selected monoclonal antibodies (mAb) for their ability to immunoprecipitate a molecule associated with CD9. A unique mAb was identified which recognizes the complement regulator CD46 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CD9 CD46 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID