TUB4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BIM1
Gene Ontology Biological Process
- microtubule depolymerization [IMP]
- microtubule nucleation [IPI]
- mitotic sister chromatid cohesion [IGI, IMP]
- mitotic spindle assembly checkpoint [TAS]
- negative regulation of microtubule depolymerization [IMP]
- nuclear migration along microtubule [IMP]
- positive regulation of microtubule polymerization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment.
γ-Tubulin has a well-established role in nucleating the assembly of microtubules, yet how phosphorylation regulates its activity remains unclear. Here, we use a time-resolved, fitness-based SGA approach to compare two γ-tubulin alleles, and find that the genetic interaction profile of γtub-Y362E is enriched in spindle positioning and cell polarity genes relative to that of γtub-Y445D, which is enriched in genes ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: fitness (APO:0000216)
- phenotype: colony size (APO:0000063)
- phenotype: vegetative growth (APO:0000106)
- phenotype: fitness (APO:0000216)
- phenotype: colony size (APO:0000063)
Additional Notes
- SGI determined using GAMER
- gammatub-Y362E
- gammatub-Y445D
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TUB4 BIM1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 202315 | |
TUB4 BIM1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 202311 | |
TUB4 BIM1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 545104 |
Curated By
- BioGRID